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90Plus 納米粒度儀應用案例-4
點擊次數：237 發布時間：2014-12-7
文獻名：Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo
作者：Coleen R Kaiser1, Michelle L Flenniken2,3, Eric Gillitzer3,4, Ann L Harmsen1, Allen G Harmsen1, Mark A Jutila1, Trevor Douglas3,5, Mark J Young3,4
1 Department of Veterinary Molecular Biology; 2 Department of Microbiology; 3 Center for Bio-Inspired Nanomaterials; 4 Department of Plant Sciences; and 5 Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, USA
摘要：Protein cage nanoparticles have the potential to serve as multifunctional cell targeted, imaging and therapeutic platforms for broad applications in medicine. However, before they find applications in medicine, their biocompatibility in vivo needs to be demonstrated. We provide here baseline biodistribution information of two different spherical protein cage nanoplatforms, the 28 nm viral Cowpea chlorotic mottle virus (CCMV) and the 12 nm heat shock protein (Hsp) cage. In na飗e and immunized mice both nanoplatforms show similar broad distribution and movement throughout most tissues and organs, rapid excretion, the absence of long term persistence within mice tissue and organs, and no overt toxicity after a single injection. These results suggest that protein cage based nanoparticles may serve as safe, biocompatible, nanoplatforms for applications in medicine.
關鍵詞：protein cage nanoparticles, Cowpea chlorotic mottle virus, heat shock protein, biodistribution